In the dark megalopolis of Méridiana, the silhouette of a mysterious character named Cybersix emerges, having escaped her creator, Doctor Von Reichter. By day, Cybersix, who adopted the male identity of Adrian Seidelman, is a literature teacher in a local high school and, by night, she 'transforms' back into Cybersix to fight Von Reichter's abominable creations and foil his plans. Soon, she's aided by her surviving brother, now named Data 7, a black bioroid panther.
A living island created by Dr Von Reichter begins making its way to Meridina harbour. It is programmed to explode once it arrives because he's tired of Jose's many failures and wants to wipe the slate clean.