In the dark megalopolis of Méridiana, the silhouette of a mysterious character named Cybersix emerges, having escaped her creator, Doctor Von Reichter. By day, Cybersix, who adopted the male identity of Adrian Seidelman, is a literature teacher in a local high school and, by night, she 'transforms' back into Cybersix to fight Von Reichter's abominable creations and foil his plans. Soon, she's aided by her surviving brother, now named Data 7, a black bioroid panther.
High school biology teacher Lucas Amato finds a tube with a glowing green ooze and takes it home with him. The next night a woman named Cybersix visits Lucas to retrieve the ooze called Sustenance. But before she has a chance to get it, a big strange man breaks into Lucas's apartment.
Cybersix's creator sends his bioroid black panther pet called Data 7 to kill her.
Jose creates a mud monster from primordial ooze which can change its shape to counter any attack and sends it after Cybersix.
Jose tries to hire a detective to help him capture Cybersix. When he refuses, Jose kidnaps his sister and will only return her in exchange for Cybersix.
Lori bumps into Jose and accidentally gets her CD switched for the CD-ROM he's using to program his tunneling robot that's going to dig into the city's treasury.
Jose uses one of Von Riecher's creations to control birds and have them attack the people of Maridiana.